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author:

Chi, Jingtian (Chi, Jingtian.) [1] | Hu, Jingfei (Hu, Jingfei.) [2] | Jin, Rongrong (Jin, Rongrong.) [3] | Zhou, Shanding (Zhou, Shanding.) [4] | Wen, Siyu (Wen, Siyu.) [5] | Jiang, Quantong (Jiang, Quantong.) [6] | Ju, Peng (Ju, Peng.) [7] | Zhai, Xiaofan (Zhai, Xiaofan.) [8]

Indexed by:

Scopus SCIE

Abstract:

Nanozymes with multifaceted functionalities have accrued substantial interest as they provide an expanded spectrum of applications in comparison to their single-active nanozymes. In this endeavor, novel Co3O4 hollow nanocages (COHNs) derived from ZIF-67 were crafted adorned with the exceptional quality of dual-enzymatic prowess by employing a simple co-precipitation and pyrolysis technique, all the while meticulously exploring the intricacies of the catalyst mechanism. Kinetic analyses ascertained that the catalytic behavior of COHNs adhered to the archetypal dynamics of Michaelis-Menten, displaying a higher affinity for 3,3 ',5,5 '-tetramethylbenzidine (TMB) compared to natural enzymes. Leveraging the exceptional peroxidase- and oxidase-mimicking activity of the COHNs, a visual colorimetric assay platform was established for the detection of H2O2, ascorbic acid (AA), and acid phosphatase (ACP), all of which showed high selectivity and good sensitivity. Significantly, by harnessing the enzyme mimic property of COHNs, quantitative detection of H2O2, AA, and ACP unveiled astoundingly low detection limits of 0.0046 mu M, 0.15 mu M, and 0.0068 mU center dot mL(-1), respectively. Moreover, the successful detection application in real samples attested to the superior stability and anti-interference ability of the colorimetric sensing system. This study not only provides a novel nanozyme boasting remarkably dual-enzymatic prowess, but also pioneers a rapid and sensitive method for environmental analysis and clinical diagnosis.

Keyword:

Biosensor Co3O4 Colorimetric detection Oxidase mimics Peroxidase mimics

Community:

  • [ 1 ] [Chi, Jingtian]Minist Nat Resources, Inst Oceanog 1, Marine Bioresource & Environm Res Ctr, Qingdao Key Lab Analyt Technol Dev & Offshore Ecoe, 6 Xianxialing Rd, Qingdao 266061, Peoples R China
  • [ 2 ] [Zhou, Shanding]Minist Nat Resources, Inst Oceanog 1, Marine Bioresource & Environm Res Ctr, Qingdao Key Lab Analyt Technol Dev & Offshore Ecoe, 6 Xianxialing Rd, Qingdao 266061, Peoples R China
  • [ 3 ] [Wen, Siyu]Minist Nat Resources, Inst Oceanog 1, Marine Bioresource & Environm Res Ctr, Qingdao Key Lab Analyt Technol Dev & Offshore Ecoe, 6 Xianxialing Rd, Qingdao 266061, Peoples R China
  • [ 4 ] [Ju, Peng]Minist Nat Resources, Inst Oceanog 1, Marine Bioresource & Environm Res Ctr, Qingdao Key Lab Analyt Technol Dev & Offshore Ecoe, 6 Xianxialing Rd, Qingdao 266061, Peoples R China
  • [ 5 ] [Chi, Jingtian]Chinese Acad Sci, Inst Oceanol, Key Lab Adv Marine Mat, CAS Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Peoples R China
  • [ 6 ] [Jiang, Quantong]Chinese Acad Sci, Inst Oceanol, Key Lab Adv Marine Mat, CAS Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Peoples R China
  • [ 7 ] [Zhai, Xiaofan]Chinese Acad Sci, Inst Oceanol, Key Lab Adv Marine Mat, CAS Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Peoples R China
  • [ 8 ] [Hu, Jingfei]Qingdao Women & Childrens Hosp, NICU, 6 Tongfu Rd, Qingdao 266000, Peoples R China
  • [ 9 ] [Jin, Rongrong]Shandong Prov Weifang Ecoenvironm Monitoring Ctr, Weifang 261044, Peoples R China
  • [ 10 ] [Zhou, Shanding]Fuzhou Univ, Sch Adv Mfg, Jinjiang 362200, Peoples R China
  • [ 11 ] [Ju, Peng]Fuzhou Univ, Sch Adv Mfg, Jinjiang 362200, Peoples R China
  • [ 12 ] [Zhai, Xiaofan]Guangxi Acad Sci, Inst Marine Corros & Protect, 98 Dalin Rd, Nanning 530007, Peoples R China

Reprint 's Address:

  • 待查

    [Ju, Peng]Minist Nat Resources, Inst Oceanog 1, Marine Bioresource & Environm Res Ctr, Qingdao Key Lab Analyt Technol Dev & Offshore Ecoe, 6 Xianxialing Rd, Qingdao 266061, Peoples R China;;[Zhai, Xiaofan]Chinese Acad Sci, Inst Oceanol, Key Lab Adv Marine Mat, CAS Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Peoples R China;;[Ju, Peng]Fuzhou Univ, Sch Adv Mfg, Jinjiang 362200, Peoples R China;;[Zhai, Xiaofan]Guangxi Acad Sci, Inst Marine Corros & Protect, 98 Dalin Rd, Nanning 530007, Peoples R China

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Source :

MICROCHIMICA ACTA

ISSN: 0026-3672

Year: 2025

Issue: 4

Volume: 192

5 . 4 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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