Nanozymes　with　multifaceted　functionalities　have　accrued　substantial　interest　as　they　provide　an　expanded　spectrum　of　applications　in　comparison　to　their　single-active　nanozymes.　In　this　endeavor,　novel　Co3O4　hollow　nanocages　(COHNs)　derived　from　ZIF-67　were　crafted　adorned　with　the　exceptional　quality　of　dual-enzymatic　prowess　by　employing　a　simple　co-precipitation　and　pyrolysis　technique,　all　the　while　meticulously　exploring　the　intricacies　of　the　catalyst　mechanism.　Kinetic　analyses　ascertained　that　the　catalytic　behavior　of　COHNs　adhered　to　the　archetypal　dynamics　of　Michaelis–Menten,　displaying　a　higher　affinity　for　3,3′,5,5′-tetramethylbenzidine　(TMB)　compared　to　natural　enzymes.　Leveraging　the　exceptional　peroxidase-　and　oxidase-mimicking　activity　of　the　COHNs,　a　visual　colorimetric　assay　platform　was　established　for　the　detection　of　H2O2,　ascorbic　acid　(AA),　and　acid　phosphatase　(ACP),　all　of　which　showed　high　selectivity　and　good　sensitivity.　Significantly,　by　harnessing　the　enzyme　mimic　property　of　COHNs,　quantitative　detection　of　H2O2,　AA,　and　ACP　unveiled　astoundingly　low　detection　limits　of　0.0046　µM,　0.15　µM,　and　0.0068　mU∙mL−1,　respectively.　Moreover,　the　successful　detection　application　in　real　samples　attested　to　the　superior　stability　and　anti-interference　ability　of　the　colorimetric　sensing　system.　This　study　not　only　provides　a　novel　nanozyme　boasting　remarkably　dual-enzymatic　prowess,　but　also　pioneers　a　rapid　and　sensitive　method　for　environmental　analysis　and　clinical　diagnosis.　©　The　Author(s),　under　exclusive　licence　to　Springer-Verlag　GmbH　Austria,　part　of　Springer　Nature　2025.