Imitating　catalytic　sites　of　natural　enzymes　is　a　promising　approach　to　accurately　improve　the　catalytic　performances　of　nanozymes.　Herein,　inspired　by　the　structure　of　natural　horseradish　peroxidase　(HRP),　threecomponent　condensation　strategy　is　unitized　to　design　histidine　(His)　functionalized　iron　porphyrin　covalent　organic　frameworks　(Fe-COF-H3)　nanozyme　with　peroxidase-like　(POD-like)　activity.　The　introduced　His　could　form　favorable　microenvironment　around　the　iron　porphyrin　structure,　enhancing　the　catalytic　capacity　of　COF　nanozyme.　Taking　advantage　of　its　excellent　POD-like　activity,　Fe-COF-H3　was　utilized　as　a　carrier　to　immobilize　urate　oxidase　(UOx)　for　the　construction　of　enzyme-nanozyme　cascade　system　(UOx@Fe-COF-H3).　The　UOx@FeCOF-H3　was　successfully　applied　for　the　colorimetric　detection　of　uric　acid　(UA)　in　biological　samples.　This　work　not　only　offers　a　new　insight　to　develop　high-efficiency　COF　nanozymes,　but　also　expands　the　application　of　COF　nanozyme　for　the　construction　of　enzyme-nanozyme　cascade　system.