In　this　study，cellulose　was　used　as　the　raw　material，and　it　was　esterified　by　polyacidic　anhydride　to　prepare　the　carboxylated　modified　cellulose　material（Cell-COOH）.　The　preparation　conditions　of　Cell-COOH　were　optimized　through　one-factor　experiment，the　structure　of　Cell-COOH　was　characterized，and　its　adsorption　properties　and　behaviors　were　investigated.　The　results　showed　that　the　equilibrium　adsorption　capacity　of　Cell-COOH　on　20　mg/L　amphetamine　solution　was　34.　59　mg/g　under　the　conditions　of　cellulose　to　homophthalic　anhydride　mass　ratio　of　1∶3，reaction　temperature　of　115　℃，and　reaction　time　of　1.　5　h.　The　adsorption　behavior　of　Cell-COOH　towards　amphetamine　was　in　accordance　with　the　Langmuir　isothermal　model　and　the　pseudo-second　kinetic　model，which　was　mainly　single-layer-chemisorp-tion，and　the　adsorption　process　was　a　self-motivated　exothermic　reaction.　The　adsorption　capacity　of　Cell-COOH　towards　amphetamine　was　92.　64%　of　first　adsorption　after　7　cycles　of　adsorption-desorption　experiments，showing　a　good　stability　and　reusability.　©　2025　China　Technical　Association　of　Paper　Industry.　All　rights　reserved.