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author:

Li, Rui (Li, Rui.) [1] | Que, Wenzhong (Que, Wenzhong.) [2] | Han, Haiyan (Han, Haiyan.) [3] | Shi, Honghui (Shi, Honghui.) [4] | Wang, Rongfeng (Wang, Rongfeng.) [5] | Qiu, Bin (Qiu, Bin.) [6]

Indexed by:

EI Scopus SCIE

Abstract:

IL-17 (interleukin-17) is a common proinflammatory cytokine and can be adopted as an important biomarker for several diseases; it is thus very necessary to design an effective method for monitoring IL-17. Herein, by preparing silver nanoparticles/graphdiyne (Ag/GDY) with simple electroless deposition as the sensing platform and methylene blue/UiO-66-NH2 MOFs (MB/MOFs) as the signaling-amplifier, a highly efficient sandwich-like electrochemical immunosensing (SLEI) platform was designed for IL-17 detection. The superior electrical property, easy preparation, large surface area, and high stability of Ag/GDY make it a desirable substrate to immobilize primary antibody of IL-17. Meanwhile, the unique structure of UiO-66-NH2 is beneficial to immobilize MB probe and secondary antibody. By optimizing experimental conditions, the MB current obtained at the as-designed SLEI platform increases along with IL-17 increase, and the related linearity is 1.0 pg mL(-1)-1.0 ng mL(-1) coupled with a low detection limit of 0.3 pg mL(-1). It is expected that the SLEI platform based on Ag/GDY and MB/MOFs shows some potential application for IL-17 detection.

Keyword:

Differential pulse voltammetry Electrochemical immunosensor Graphdiyne Interleukin-17 MOFs UiO-66-NH2

Community:

  • [ 1 ] [Li, Rui]Fuzhou First Gen Hosp, Dept Dermatol, Fuzhou, Peoples R China
  • [ 2 ] [Que, Wenzhong]Fuzhou First Gen Hosp, Dept Rheumatol, Fuzhou, Peoples R China
  • [ 3 ] [Han, Haiyan]Fuzhou First Gen Hosp, Dept Geriatr Med, Fuzhou, Peoples R China
  • [ 4 ] [Shi, Honghui]Fuzhou First Gen Hosp, Dept Pulm & Crit Care Med, Fuzhou, Peoples R China
  • [ 5 ] [Wang, Rongfeng]Fujian Fuqing City Hosp, Dept Otorhinolaryngol, Fuqing, Peoples R China
  • [ 6 ] [Qiu, Bin]Fuzhou Univ, Key Lab Analyt Sci Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ, Fuzhou, Peoples R China

Reprint 's Address:

  • [Li, Rui]Fuzhou First Gen Hosp, Dept Dermatol, Fuzhou, Peoples R China;;[Qiu, Bin]Fuzhou Univ, Key Lab Analyt Sci Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Food Safety, Minist Educ, Fuzhou, Peoples R China

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Source :

MICROCHIMICA ACTA

ISSN: 0026-3672

Year: 2025

Issue: 5

Volume: 192

5 . 4 0 0

JCR@2023

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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