Objective:　To　observe　the　effect　of　hawthorn　red　pigment　(HRP)　on　meridian　voltage　in　20　volunteers　over　a　period　of　90　days.　Methods:　The　characteristic　absorption　peak　of　HRP　was　determined　by　ultraviolet-visible　spectroscopy　full-wavelength　absorption　analysis　scanning,　and　its　solution　particle　size　was　measured　by　Nano-ZS　Malvern　laser　particle　size　analyzer.　Volunteers　were　required　to　take　a　100　mL　HRP　solution　containing　4.0　g　hawthorn　powder　three　times　a　day　after　meals.　The　measurement　time　for　meridian　surface　voltage　was　from　09:00　to　11:00　after　breakfast,　with　the　first　administration　at　09:30.　Results:　HRP　had　a　characteristic　absorption　peak　at　280　nm,　and　the　average　particle　size　was　137.03　±　1.44　nm.　Among　the　five　volunteers　who　completed　the　experiment,　the　spleen　meridian　had　the　most　significant　decompression　effect,　with　the　initial　voltage　dropping　from　14.11　to　−7.25　mV　on　the　seventh　day　(p　＜　0.05).　In　addition,　the　heart　meridian　voltage　gained　the　most　within　90　min,　reaching　18.55　mV　on　the　28th　day　(p　＜　0.05),　while　the　pericardium　meridian　had　the　greatest　loss,　with　the　maximum　being　9.24　mV　on　the　28th　day　(p　＜　0.05)　and　9.36　mV　on　the　90th　day　(p　＜　0.05).　Conclusion:　HRP　has　the　effects　of　activating　the　heart　meridian,　boosting　the　mind,　and　relieving　the　pressure　of　the　pericardium　meridian.　Regular　consumption　can　reduce　the　stress　on　the　liver,　spleen,　and　kidney　meridians,　especially　with　a　significant　improvement　in　the　spleen　meridian　within　28　days.　This　finding　is　consistent　with　the　traditional　efficacy　of　hawthorn　in　strengthening　the　spleen.　Copyright　2025,　Mary　Ann　Liebert,　Inc.,　publishers.