A　RuOx-modified　V2O5-WO3-TiO2　(VWT)　mixed　oxide　catalyst　was　prepared　by　co-impregnation,　which　exhibited　excellent　SO2　and　H2O(g)　tolerance　under　low-temperature　conditions.　The　enhancement　of　water　and　sulfur　poisoning　resistance　by　RuOx　doping　to　VWT　catalytic　materials　was　examined　under　low-temperature　environments　using　multiple　characterization　techniques.　Experimental　results　indicated　that　RuOx　substantially　enhanced　the　low-temperature　performance　of　VWT　catalysts　against　water-sulfur　poisoning,　inhibited　the　sulfation　of　the　carrier　as　well　as　the　active　V　species,　enhanced　the　adsorption　and　activation　capacity　of　oxygen,　and　alleviated　the　competing　adsorption　relationship　among　NH3　and　NO　and　H2O(g)　+　SO2.　In　addition,　in　situ　infrared　spectroscopy　revealed　that　RuOx　generates　sacrificial　adsorption　sites　on　the　catalyst　surface,　thereby　preventing　active　site　sulfation　and　preserving　the　operation　of　the　Langmuir-Hinshelwood　mechanism　at　low　temperature.