Herein　we　disclose　the　report　on　the　synthesis　of　alpha-trifluoromethylseleno-substituted　ketone　derivatives　via　copper-mediated　trifluoromethylselenolation　of　alpha-bromoketones　with　[(bpy)Cu(SeCF3)](2)　1.　A　broad　range　of　substituted　2-bromoacetophenone　substrates　were　found　to　react　smoothly　with　1　in　the　presence　of　3　equiv　of　K3PO4　to　afford　the　corresponding　alpha-trifluoromethylseleno-substituted　ketones　in　good　yields.　A　wide　range　of　functional　groups　were　well　tolerated　and　the　reaction　conditions　are　amenable　to　scale　up.