An　attempt　to　improve　hydrophilicity　and　anti-fouling　properties　of　PVDF　membranes,　a　novel　amphiphilic　zwitterionic　copolymer　poly(vinylidene　fluoride)-graft-poly(sulfobetaine　methacrylate)　(PVDF-g-PSBMA)　was　firstly　synthesized　by　atom　transfer　radical　polymerization　(ATRP)　and　used　as　amphiphilic　copolymer　additive　in　the　preparation　of　PVDF　membranes.　The　PVDF-g-PSBMA/PVDF　blend　membranes　were　prepared　by　immersion　precipitation　process.　Fourier　transform　infrared　attenuated　reflection　spectroscopy　(FTIR-ATR)　and　X-ray　photoelectronic　spectroscopy　(XPS)　measurements　confirmed　that　PSBMA　brushes　from　amphiphilic　additives　were　preferentially　segregated　to　membrane-coagulant　interface　during　membrane　formation.　The　morphology　of　membranes　was　characterized　by　scanning　electron　microscopy　(SEM).　Water　contact　angle　measurements　showed　that　the　surface　hydrophilicity　of　PVDF　membranes　was　improved　significantly　with　the　increasing　of　amphiphilic　copolymer　PVDF-g-PSBMA　in　cast　solution.　Protein　static　adsorption　experiment　and　dynamic　fouling　resistance　experiment　revealed　that　the　surface　enrichment　of　PSBMA　brush　endowed　PVDF　blend　membrane　great　improvement　of　surface　anti-fouling　ability.　(C)　2012　Elsevier　B.V.　All　rights　reserved.