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Abstract：
A method for the determination of methylene blue (MB) and its metabolites (azure A, azure B and azure C) in rat blood by CE-electrospray ionization mass spectrometry (CE-ESI-MS) was developed in this paper. Different analytical parameters were investigated in detail such as pH and concentration of separation buffer, and ESI-MS instrumental parameters. Under the optimum conditions, MB and its metabolites were separated and detected in 27.3 min. LODs (defined as S/N = 3) of this method were 0.22, 0.25, 0.10 and 0.30 mu g/mL for MB, azure A, azure B and azure C, respectively. To get a satisfactory extraction efficiency of MB and its metabolites in rat blood, different extraction solutions were studied. By using this method, MB and its metabolites (azure A, azure B and azure C) were successfully analyzed in rat blood samples.
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ELECTROPHORESIS
ISSN： 0173-0835
Year： 2011
Issue： 6-7
Volume： 32
Page： 659-664
3 . 3 0 3
JCR@2011
3 . 0 0 0
JCR@2023
ESI Discipline： CHEMISTRY;
JCR Journal Grade：1
CAS Journal Grade：2
Cited Count：
WoS CC Cited Count： 7
SCOPUS Cited Count： 7
ESI Highly Cited Papers on the List： 0 Unfold All
WanFang Cited Count：
Chinese Cited Count：
30 Days PV： 2
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