The　synthesis　and　characterizations　of　eight　metal　phthalocyanines　containing　piperazine　(SPEO)(4)PcM,　where　M=Zn,　Ni,　Co　or　Cu,　SPEO=2-[4-(2-sulfonic　ethyl)　piperazine-1-yl]　ethyoxyl　were　studied.　The　UV-Vis　absorption　spectra,　fluorescence　emission　spectra　and　capacity　of　singlet　oxygen　yield　with　DPBF　as　capturer　were　examined.　The　results　show　that　all　complexes　possess　very　high　molar　extinction　coefficient,　fluorescence　quantum　yield,　rate　of　singlet　oxygen　yield.　Zinc　phthalocyanine　complex　beta-(SPEO)(4)PcZn　possesses　the　best　photoinhibition　through　photodynamic　inhibition　of　BEL7402　liver　cancer　cells,　82%　cancer　cells　are　inhibited　after　it　is　Irradiated　by　1.2　J　photo　dosage　of　670　nm　red-light　laser　when　the　concentration　of　beta-(SPEO)(4)PcZn　with　10　mu　mol　center　dot　L-1　is　used.