In　respond　to　the　dynamic　evolution　of　complex　design,　a　model　of　bio-inspired　innovation　design　process　based　on　Concept-Knowledge　theory　is　constructed.　Firstly,　the　transformation　of　design　elements　is　developed　and　the　design　space　with　description　of　Problem-Biology-Technology　is　standardized.　Then,　using　the　biological　convergence　theory　and　the　analogy　transfer　methodology,　the　knowledge　attributes　are　extracted　for　function-strategy-action-structure　of　biological　prototype　at　each　level,　and　the　enlightenment　are　obtained　for　engineering　problems.　Furthermore,　the　bio-inspired　design　space　and　its　operators　are　defined　to　establish　the　bionic　operator　process　model　in　light　of　C-K(Concept-Knowledge)　theory.　Finally,　with　the　integration　of　various　knowledge　attributes　of　multi-organisms,　a　multi-level　description　is　obtained　for　engineering　problems,　and　viable　product　solutions　to　multi-biological　prototypes　are　established.　Taking　the　pipeline　micro-robot　as　an　example,　it＇s　feasible　to　verify　the　bio-inspired　design　process　model　on　the　basis　of　C-K　theory.　©　2020　Journal　of　Mechanical　Engineering.