In　the　present　study,　corosolic　acid　(CA)　was　extracted　and　separated　from　Folium　Eriobotryae.　A　Cu2+-induced　low　density　lipoprotein　(LDL)　oxidation　model　was　employed　to　evaluate　the　inhibitory　effect　of　CA　on　LDL　oxidation　in　vitro,　and　a　human　aortic　endothelial　cell　(HAEC)　model　of　oxidative　damage　induced　by　(2,2＇-azobis-2-methylpropanimidamide　dihydrochloride,　AAPH)　was　employed　to　evaluate　the　protective　effect　of　CA　on　oxidative　damage.　In　the　dose　range　of　10-100　μmol/L,　CA　effectively　extended　the　lag　time　of　the　Cu2+-induced　LDL　oxidation　process,　reduced　the　area　under　the　oxidation　kinetic　curve　(AUC)　and　inhibited　the　generation　of　lipid　peroxide　indicating　that　CA　could　effectively　inhibit　LDL　oxidation　induced　by　Cu2+.　In　the　cellular　experiment　at　the　dose　range　of　2-10　μmol/L,　CA　effectively　reduced　LDH　leakage　induced　by　AAPH,　maintained　the　integrity　of　cell　structure,　enhanced　the　activities　of　antioxidant　enzymes　such　as　superoxide　dismutase　(SOD)　and　glutathione　peroxidase　(GPx)　and　therefore　oxidative　stress　resistance,　reduced　the　proportion　of　sub-G1/G0　cells　and　necrosis　or　apoptosis　induced　by　AAPH.　These　results　demonstrated　that　CA　could　elevate　cellular　antioxidant　capacity,　maintain　the　integrity　of　cellular　structure,　and　ultimatelyp　rotect　HAECs　against　oxidative　stress　damage　induced　byA　APH.　©　2017,　China　Food　Publishing　Company.　All　right　reserved.