An　optimum　fermentation　medium　suitable　for　brewing　Hongqu　glutinous　rice　wine　by　Monascus　strain　L　(M.　kaoliang)　in　submerged　fermentation　were　studied.　In　this　paper,　parameters　affecting　glucoamylase,　red　pigment　and　citrinin　production　in　Monascus　kaoliang　L　were　optimized　under　submerged　cultivation.　A　Plackett-Burman　design　was　first　used　to　sift　the　important　factors　from　seven　related　factors.　Then,　the　central　composite　design　and　desirability　function　were　used　for　further　multiple　response　optimization.　Maximum　glucoamylase　activity　and　monascus　pigment　production,　and　minimum　citrinin　production　were　obtained　in　the　optimized　cultivation　parameters　containing　rice　flour　3%,　glucose　1.25%,　monosodium　glutamate　2.23%,　(NH4)2SO4　0.97%,　KH2PO4　0.3%,　MgSO4　·7H20　0.07%,　MnSO4　·　H2O　0.007%.　Under　the　optimized　fermentation　conditions,　the　production　of　glucoamylase　activity　increased　from　240.48　U/mL　to　453.57　U/mL,　monascus　pigment　production　basic　maintain　the　original　level,　and　citrinin　production　decreased　from　91.79　U/mL　to　16.42　U/mL.