Antimony　sulfide　(Sb2S3)　with　high　absorption　coefficient　reveals　great　potential　for　photodetectors　(PDs)　in　various　fields　of　military　and　national　economy.　A　new　type　of　depleted　Sb2S3　thin　film　photoconductive　detector　by　using　titanium　dioxide　(TiO2)　interlayer　with　the　structure　of　Au/(glass/TiO2:)Sb2S3/Au　is　designed.　Compared　with　normal　Au/Sb2S3/Au　devices,　the　depleted　Sb2S3　PDs　obtain　a　higher　switching　ratio　of　90,　greatly　enhancing　responsivity　and　specific　detectivity.　Owing　to　the　electric　field　of　the　depletion　region,　the　response　time　significantly　decreases　from　23.2　to　0.6　ms.　In　addition,　the　anisotropic　Sb2S3　film　with　[120]　dominated　horizontal　orientation　is　suitable　for　polarized　light　detection.　The　peak-to-valley　ratio　of　the　depleted　Sb2S3　PD　reaches　1.3　at　polarized　light.　The　results　and　methods　of　this　study　are　expected　to　expand　the　application　of　PDs　based　on　Sb2S3　films.