Development　of　metal-organic　framework　(MOF)　films　is　of　great　importance　to　expand　their　applications.　Herein,　we　report　a　facile　and　universal　method　of　liquid-phase　epitaxial　(LPE)　layer　by　layer　(LBL)　brushing　approach　for　fabricating　MOF　films　on　various　substrates　in　a　high-throughput　fashion.　This　MOF　films　preparation　method　offers　a　great　prospective　to　cost-effectively　construct　films　with　short　preparation　time　and　little　reagent　consumption.　Moreover,　this　LBL　brushing　approach　has　been　implemented　successfully　to　assemble　various　MOF　films,　including　HKUST-1,　zeolitic　imidazolate　framework-8　(ZIF-8),　Cu(bdc),　and　Cu2(L)2P　(L　=　bdc,　ndc,　and　cam;　P　=　dabco　and　bipy).　Afterwards,　the　classic　MOF　HKUST-1　and　ZIF-8　films　were　grown　on　sensor　chip　electrode　and　porous　fiber　support　for　good　volatile　organic　compounds　(VOCs)　selective　sensing　and　water　purification　applications.　This　study　demonstrates　that　this　LBL　brushing　preparation　method　can　be　employed　to　synthesize　various　MOF　films　with　a　variety　of　characteristics　to　realize　their　sensing　and　separation　applications.[Figure　not　available:　see　fulltext.]　©　2024,　Tsinghua　University　Press.