With　an　estimated　global　prevalence　of　32.4%,　non-alcoholic　fatty　liver　disease　(NAFLD)　is　currently　the　most　prevalent　chronic　liver　condition.　The　marine　ecosystem,　distinguished　by　its　distinctive　environmental　characteristics,　is　a　treasure　trove　of　novel　lead　compounds　possessing　unique　chemical　structures,　offering　promising　avenues　for　the　development　of　new　therapeutic　agents　or　dietary　supplement　targeting　NAFLD.　Marine　bioactive　substances　from　natural　products,　such　as　polysaccharides,　polyphenols,　polyunsaturated　fatty　acids,　and　peptides,　have　been　shown　to　benefit　liver　health　by　alleviating　metabolic　dysfunction　through　multiple　mechanisms.　This　paper　reviews　the　effects　of　marine　bioactive　substances　from　various　marine　entities,　including　marine　fauna,　flora,　and　microorganisms,　on　the　regulation　of　NAFLD.　A　brief　overview　of　the　predominant　pathogenic　mechanisms　underlying　the　disease　is　also　provided,　thereby　establishing　a　critical　link　between　the　therapeutic　potential　of　marine　bioactive　substances　and　the　management　of　NAFLD.