Microbe-imprinted polymers for rapid drug-resistant bacteria recognition - Details

author：

Indexed by：

Scopus

Abstract：

The　rise　of　antibiotic-resistant　bacteria　poses　a　serious　global　health　threat,　highlighting　the　urgent　need　for　novel　strategies　beyond　conventional　antibiotic　therapies.　This　study　explores　the　potential　of　microbe-imprinted　polymers　(MIPs)　as　innovative,　pathogen-specific　affinity　agents.　Utilizing　microbial　surface-initiated　polymerization,　MIPs　are　in-situ　synthesized　on　the　surface　of　target　microbes,　creating　flexible　heteropolymers　that　precisely　replicate　microbial　surface　structures.　This　method　exhibits　high　affinity　(KD　=　2.7×108　CFU/mL　for　E.　coli)　and　selectivity　at　the　strain　level.　MIPs　offer　significant　advantages　over　traditional　antibodies,　including　greater　stability,　cost-effectiveness,　and　a　broader　spectrum　of　binding　capabilities,　making　them　effective　for　identifying　and　targeting　various　microbial　strains,　including　unidentified　or　drug-resistant　variants.　Moreover,　their　favorable　biocompatibility　and　functional　resilience　in　diverse　environments　position　MIPs　as　promising　candidates　for　rapid　pathogen　detection　and　therapeutic　applications.　This　research　paves　the　way　for　advanced　biomimetic　materials　in　microbe-specific　diagnostics　and　combating　infections,　addressing　the　critical　need　for　effective　tools　in　antibiotic　resistance　surveillance.　©　2025

Keyword：

Affinity Antibiotic resistance Antibody mimics Microbe-imprinted polymers Microbial recognition

Community：

[ 1 ] [Wu Y.]Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350001, China
[ 2 ] [Wu Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Zhou K.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Li W.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Huan M.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Yu Z.]Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Yan F.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Hong H.]National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, 72079, AR, United States
[ 9 ] [Tang D.]Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Guo Y.]Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350001, China
[ 11 ] [Guo Y.]Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Clinical Research Center for Severe Acute Cardiovascular Diseases, Fuzhou, 350001, China
[ 12 ] [Guo Y.]School of Medicine, Fuzhou University, Fuzhou, 350108, China
[ 13 ] [Weng Z.]Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350001, China
[ 14 ] [Weng Z.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 15 ] [Weng Z.]Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Clinical Research Center for Severe Acute Cardiovascular Diseases, Fuzhou, 350001, China
[ 16 ] [Weng Z.]School of Medicine, Fuzhou University, Fuzhou, 350108, China