High-entropy　alloys　(HEAs)　show　great　potential　for　catalyzing　complex　multi-step　reactions,　but　optimizing　their　parameters,　i.e.,　composition,　but　also　their　crystallinity　and　morphology,　remains　a　significant　challenge.　In　this　study,　FeCoNiMoW　HEAs　are　synthesized　into　either　amorphous　nanosheets　(HEANS)　or　crystalline　nanoparticles　(HEANP),　which　are　then　used　to　catalyze　the　lithium-sulfur　(Li-S)　reaction　of　Li-S　batteries　(LSBs).　Evaluations　in　symmetric　cells,　coin　cells,　and　pouch　cells　reveal　that　HEANS　significantly　enhance　LSB　performance,　achieving　initial　discharge　capacities　up　to　1632　mAh　g-1.　The　batteries　also　exhibit　excellent　cycling　stability　over　1000　cycles　at　3Cand　maintain　high-rate　performance　up　to　10C　with　a　capacity　of　614　mAh　g-1.　Comprehensive　in　situ　analyses　and　density　functional　theory　calculations　demonstrate　that　amorphous　HEANS　provide　more　active　sites,　better　ionic　conductivity　and　stronger　chemical　interactions　with　lithium　polysulfides　(LiPS).　These　properties　effectively　suppress　the　shuttle　effect,　promote　the　complete　S8　-＞　Li2S　conversion　by　reducing　the　impedance　of　the　solid-electrolyte　interphase,　and　accelerate　the　Li2S4　-＞　Li2S2　step　by　lowering　the　nucleation　energy　barrier.　Overall,　this　study　highlights　the　superior　catalytic　properties　of　amorphous　2D　HEAs　in　LSBs　and　offers　new　insights　into　the　mechanisms　of　LiPS　conversion.