The　shaking　table　tests　are　conducted　on　a　5-floor　steel　frame　model　with　a　scale　down　of　1:6.　The　traditional　anti-seismic　structure　and　isolation　structures　with　isolation　layer　in　different　position　are　adopted.　The　results　indicate　that　the　natural　vibration　periods　of　isolation　structure　are　longer　than　anti-seismic　structure,　and　when　the　isolation　layer　is　located　in　a　lower　position,　the　period　becomes　longer　and　the　damping　effect　is　better.