Over-exploitation　of　fossil　energy　has　led　to　the　formation　of　enormous　amounts　of　oily　wastewater,　which　is　increasingly　polluting　the　environment　of　water　bodies.　The　Ti3C2Tx-modified　separation　ma-terial　is　limited　by　surface　roughness　and　surface　chemical　composition,　and　the　permeation　flux　de-creases　significantly　during　continuous　testing.　In　this　study,　silver-loaded　polydopamine　nanospheres　(nano-AgPNPs)　as　antioxidants　were　prepared　by　in-situ　reduction　from　Ag+　ions　and　polydopamine　nanospheres,　and　then　they　self-assembled　with　Ti3C2Tx　nanosheets　to　obtain　hierarchical　micro-nano　structural　nano-AgPNPs　modified　Ti3C2Tx　[(AgPNPs)xT　(　x　=　0.25,　0.5,　0.75,　and　1)].　Because　of　their　strong　reduction　properties,　nano-AgPNPs　antioxidants　can　effectively　protect　the　active　edges　of　Ti3C2Tx　from　dissolved　oxygen,　and　greatly　improve　the　oxidation　resistance　of　Ti3C2Tx　nanosheets,　with　no　signif-icant　changes　in　morphology　and　physical　phase　after　long-term　placement.　(AgPNPs)xT　formed　un-derwater　oleophobic　interfaces　with　the　hierarchical　structure　on　polyurethane　(PU)　sponge　to　prepare　(AgPNPs)xT@PU　separation　sponges.　Among　them,　(AgPNPs)0.5T@PU　sponge　showed　the　highest　compre-hensive　performance　with　separation　efficiency　higher　than　99.6%　for　various　oil-water　mixtures,　espe-cially　high-throughput　and　permeation　flux　up　to　247,787　L　m-2　h-1　for　cyclohexane-water　mixtures.　In　addition,　nano-AgPNPs　greatly　broadened　the　layer　spacing　of　Ti3C2Tx　and　can　form　a　functionalized　in-terface　of　modified　Ti3C2Tx　on　polyamide　(PA)　membrane　and　provide　additional　permeation　channels,　which　enabled　the　(AgPNPs)0.5T@PA　membrane　to　have　excellent　toluene-water　emulsion　separation　effi-ciency　up　to　99.6%.(c)　2023　Published　by　Elsevier　Ltd　on　behalf　of　The　editorial　office　of　Journal　of　Materials　Science　&　Technology.