• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

author:

Cao, Yongjian (Cao, Yongjian.) [1] | Zhang, Haijie (Zhang, Haijie.) [2] | Qiu, Mengjie (Qiu, Mengjie.) [3] | Zheng, Yunquan (Zheng, Yunquan.) [4] (Scholars:郑允权) | Shi, Xianai (Shi, Xianai.) [5] (Scholars:石贤爱) | Yang, Jianmin (Yang, Jianmin.) [6] (Scholars:杨建民)

Indexed by:

EI Scopus SCIE

Abstract:

The simultaneous regeneration of articular cartilage and subchondral bone is a major challenge. Bioinspired scaffolds with distinct regions resembling stratified anatomical architecture provide a potential strategy for osteochondral defect repair. Here, we report the development of an injectable and bilayered hydrogel scaffold with a strong interface binding force. In this bilayer hydrogel, composed of carbonyl hydrazide grafted collagen (COL-CDH) and oxidized chondroitin sulfate (OCS), which are derivatives of osteochondral tissue components, in combination with poly (ethylene glycol) diacrylate (PEGDA), functions as a cartilage layer; while zinc-doped hydroxyapatite acts as a subchondral bone layer that is based on the cartilage layer. The strong interface be-tween the two layers involves dynamic amide bonds formed between COL-CDH and OCS, and permanent C-C bonds formed by PEGDA radical reactions. This bilayer hydrogel can be used to inoculate adipose mesenchymal stem cells which can then differentiate into chondrocytes and osteoblasts, secreting glycosaminoglycan, and promoting calcium deposition. This accelerates the regeneration of cartilage and subchondral bone. Micro-CT and tissue staining revealed an increase in the amount of bone present in new subchondral bone, and new tis-sues with a structure similar to normal cartilage. This study therefore demonstrates that injectable bilayer hydrogels are a promising scaffold for repairing osteochondral defects.

Keyword:

Adipose-derived mesenchymal stem cells Bilayered scaffold Biomimetic Injectable hydrogel Osteochondral regeneration

Community:

  • [ 1 ] [Cao, Yongjian]Fuzhou Univ, Coll Chem, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 2 ] [Zhang, Haijie]Fuzhou Univ, Coll Chem, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 3 ] [Qiu, Mengjie]Fuzhou Univ, Coll Chem, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 4 ] [Zheng, Yunquan]Fuzhou Univ, Coll Chem, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 5 ] [Shi, Xianai]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 6 ] [Yang, Jianmin]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 7 ] [Zheng, Yunquan]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 8 ] [Shi, Xianai]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 9 ] [Yang, Jianmin]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 10 ] [Zheng, Yunquan]Fuzhou Univ, Int Joint Lab Intelligent Hlth Care, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 11 ] [Shi, Xianai]Fuzhou Univ, Int Joint Lab Intelligent Hlth Care, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 12 ] [Yang, Jianmin]Fuzhou Univ, Int Joint Lab Intelligent Hlth Care, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • [Zheng, Yunquan]Fuzhou Univ, Coll Chem, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Yang, Jianmin]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Zheng, Yunquan]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Yang, Jianmin]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Zheng, Yunquan]Fuzhou Univ, Int Joint Lab Intelligent Hlth Care, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Yang, Jianmin]Fuzhou Univ, Int Joint Lab Intelligent Hlth Care, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;

Show more details

Related Keywords:

Source :

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ISSN: 0141-8130

Year: 2023

Volume: 257

7 . 7

JCR@2023

7 . 7 0 0

JCR@2023

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 11

SCOPUS Cited Count: 7

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

Online/Total:170/10018480
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1