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author:

Zhang, Junyi (Zhang, Junyi.) [1] | Deng, Ye (Deng, Ye.) [2] | Chen, Lifen (Chen, Lifen.) [3] | Luo, Fang (Luo, Fang.) [4] (Scholars:罗芳) | Weng, Zuquan (Weng, Zuquan.) [5] (Scholars:翁祖铨) | Lin, Cuiying (Lin, Cuiying.) [6] (Scholars:林翠英) | Qiu, Bin (Qiu, Bin.) [7] (Scholars:邱彬) | Guo, Longhua (Guo, Longhua.) [8] | Lin, Zhenyu (Lin, Zhenyu.) [9] (Scholars:林振宇)

Indexed by:

EI Scopus SCIE

Abstract:

T-2 toxin is widely found in nature and also contaminates field crops and grain storage, posing a potential threat to human health. In this study, an ultra-sensitive electrochemiluminescence (ECL) aptasensor has been developed for the detection of T-2 toxin using Ti3C2 MXene-based nanomaterials functionalized with gold nanorods (AuNRs) and Ru(bpy)32+ (Ti3C2@AuNRs-Ru) as the luminescent indicator. Specifically, gold nanorods are grown in situ on the surface of Ti3C2 MXene, and Ru(bpy)32+ is loaded onto Ti3C2@AuNRs via electrostatic force to form the Ti3C2@AuNRs-Ru luminescent probe, which is then modified on the electrode surface. The aptamer of T-2 toxin is connected to the electrode surface through Au-S bonds, and then the capture chain (cDNA) with a quenching probe of ferrocene is introduced to the system. Ferrocene can quench the luminescence of the probe, reducing the ECL signal. In the presence of T-2 toxin, it binds to the aptamer with higher affinity, so the quenching probe is competed down, resulting in the recovery of the ECL signal. The increase in ECL signal is linearly correlated with the logarithm of T-2 toxin concentration, with the detection range of 50 fg/mL to 50 ng/ mL and a detection limit of 6.44 fg/mL. This strategy utilizes the high catalytic activity and excellent conductivity of MXene, improving the sensitivity significantly. The proposed sensor has been successfully applied for the detection of actual samples and provides a new strategy for the detection of hazardous pollutants.

Keyword:

Electrochemiluminescent aptasensor Hazardous pollutant Nanomaterials T-2 toxin

Community:

  • [ 1 ] [Zhang, Junyi]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Fujian, Peoples R China
  • [ 2 ] [Deng, Ye]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Fujian, Peoples R China
  • [ 3 ] [Luo, Fang]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Fujian, Peoples R China
  • [ 4 ] [Weng, Zuquan]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Fujian, Peoples R China
  • [ 5 ] [Zhang, Junyi]Fuzhou Univ, Coll Chem, MOE Key Lab Anal & Detect Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Fujian, Peoples R China
  • [ 6 ] [Luo, Fang]Fuzhou Univ, Coll Chem, MOE Key Lab Anal & Detect Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Fujian, Peoples R China
  • [ 7 ] [Lin, Cuiying]Fuzhou Univ, Coll Chem, MOE Key Lab Anal & Detect Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Fujian, Peoples R China
  • [ 8 ] [Qiu, Bin]Fuzhou Univ, Coll Chem, MOE Key Lab Anal & Detect Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Fujian, Peoples R China
  • [ 9 ] [Lin, Zhenyu]Fuzhou Univ, Coll Chem, MOE Key Lab Anal & Detect Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Saf, Fuzhou 350116, Fujian, Peoples R China
  • [ 10 ] [Chen, Lifen]Jiaxing Univ, Coll Biol, Jiaxing Key Lab Mol Recognit & Sensing, Chem Sci & Engn, Jiaxing 314001, Peoples R China
  • [ 11 ] [Guo, Longhua]Jiaxing Univ, Coll Biol, Jiaxing Key Lab Mol Recognit & Sensing, Chem Sci & Engn, Jiaxing 314001, Peoples R China
  • [ 12 ] [Lin, Zhenyu]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
  • [ 13 ] [Chen, Lifen]Jiaxing Univ, Coll Biol, Chem Sci & Engn, Jiaxing 314001, Peoples R China

Reprint 's Address:

  • [Luo, Fang]Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Fujian, Peoples R China;;[Lin, Zhenyu]Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China;;[Chen, Lifen]Jiaxing Univ, Coll Biol, Chem Sci & Engn, Jiaxing 314001, Peoples R China;;

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Source :

ELECTROCHIMICA ACTA

ISSN: 0013-4686

Year: 2023

Volume: 475

5 . 5

JCR@2023

5 . 5 0 0

JCR@2023

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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