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author:

Sun, Xiaohan (Sun, Xiaohan.) [1] | Zhang, Nanxin (Zhang, Nanxin.) [2] | Chen, Longhui (Chen, Longhui.) [3] | Lai, Yuchao (Lai, Yuchao.) [4] | Yang, Shasha (Yang, Shasha.) [5] | Li, Qiang (Li, Qiang.) [6] | Zheng, Yunquan (Zheng, Yunquan.) [7] (Scholars:郑允权) | Chen, Li (Chen, Li.) [8] (Scholars:陈立) | Shi, Xianai (Shi, Xianai.) [9] (Scholars:石贤爱) | Yang, Jianmin (Yang, Jianmin.) [10] (Scholars:杨建民)

Indexed by:

EI Scopus SCIE

Abstract:

In anterior cruciate ligament (ACL) repair methods, the continuous enzymatic erosion of synovial fluid can impede healing and potentially lead to repair failure, as well as exacerbate articular cartilage wear, resulting in joint degeneration. Inspired by the blood clot during medial collateral ligament healing, we developed a composite scaffold comprising collagen (1 %, w/v) and polyvinyl alcohol (5 %, w/v) combined with platelet-rich plasma (PRP). The composite scaffold provides a protective barrier against synovial erosion for the ruptured ACL, while simultaneously facilitating tissue repair, thereby enhancing the efficacy of ACL repair techniques. The composite scaffold is primarily formed through hydrogen bonding between molecular chains and physical cross- linking of microcrystalline regions using a simple cyclic freeze-thaw method, resulting in improved mechanical properties and an extended degradation period. The maximum tensile fracture load of the composite scaffold reached 5.99 +/- 0.30 N. The incorporation of PRP facilitates cell migration, proliferation, and blood vessel growth by enabling slow release of various growth factors. In vivo results demonstrate that this composite scaffold promotes rabbit hindlimb rupture ACL healing by stimulating fibroblast proliferation, collagen deposition, microvascular formation, and proprioceptor generation. Furthermore, it effectively reduces meniscus and cartilage wear while mitigating bone arthritis and joint degenerative diseases. Overall, our proposed composite scaffold holds great promise as a candidate for ACL healing.

Keyword:

Anterior cruciate ligament Biodegradable scaffold Collagen Platelet-rich plasma Polyvinyl alcohol

Community:

  • [ 1 ] [Sun, Xiaohan]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 2 ] [Chen, Longhui]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 3 ] [Yang, Shasha]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 4 ] [Chen, Li]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 5 ] [Shi, Xianai]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 6 ] [Yang, Jianmin]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 7 ] [Zhang, Nanxin]Fujian Med Univ, Dept Orthoped, Affiliated Hosp 1, 20 Chazhong Rd, Fuzhou 350004, Peoples R China
  • [ 8 ] [Lai, Yuchao]Fujian Med Univ, Dept Orthoped, Affiliated Hosp 1, 20 Chazhong Rd, Fuzhou 350004, Peoples R China
  • [ 9 ] [Li, Qiang]Fujian Med Univ, Dept Orthoped, Affiliated Hosp 1, 20 Chazhong Rd, Fuzhou 350004, Peoples R China
  • [ 10 ] [Zheng, Yunquan]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 11 ] [Chen, Li]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 12 ] [Shi, Xianai]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China
  • [ 13 ] [Yang, Jianmin]Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Technol, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • 杨建民

    [Yang, Jianmin]Fuzhou Univ, Coll Biol Sci & Engn, 2 Xueyuan Rd, Fuzhou 350108, Peoples R China;;[Li, Qiang]Fujian Med Univ, Dept Orthoped, Affiliated Hosp 1, 20 Chazhong Rd, Fuzhou 350004, Peoples R China

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Source :

BIOMATERIALS ADVANCES

Year: 2025

Volume: 169

5 . 5 0 0

JCR@2023

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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